Common variants in WFS1 confer risk of type 2 diabetes
MS Sandhu, MN Weedon, KA Fawcett, J Wasson… - Nature …, 2007 - nature.com
Nature genetics, 2007•nature.com
We studied genes involved in pancreatic β cell function and survival, identifying associations
between SNPs in WFS1 and diabetes risk in UK populations that we replicated in an
Ashkenazi population and in additional UK studies. In a pooled analysis comprising 9,533
cases and 11,389 controls, SNPs in WFS1 were strongly associated with diabetes risk. Rare
mutations in WFS1 cause Wolfram syndrome; using a gene-centric approach, we show that
variation in WFS1 also predisposes to common type 2 diabetes.
between SNPs in WFS1 and diabetes risk in UK populations that we replicated in an
Ashkenazi population and in additional UK studies. In a pooled analysis comprising 9,533
cases and 11,389 controls, SNPs in WFS1 were strongly associated with diabetes risk. Rare
mutations in WFS1 cause Wolfram syndrome; using a gene-centric approach, we show that
variation in WFS1 also predisposes to common type 2 diabetes.
Abstract
We studied genes involved in pancreatic β cell function and survival, identifying associations between SNPs in WFS1 and diabetes risk in UK populations that we replicated in an Ashkenazi population and in additional UK studies. In a pooled analysis comprising 9,533 cases and 11,389 controls, SNPs in WFS1 were strongly associated with diabetes risk. Rare mutations in WFS1 cause Wolfram syndrome; using a gene-centric approach, we show that variation in WFS1 also predisposes to common type 2 diabetes.
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