[HTML][HTML] CCAAT/enhancer-binding proteins (C/EBP) β and δ activate osteocalcin gene transcription and synergize with Runx2 at the C/EBP element to regulate bone …
S Gutierrez, A Javed, DK Tennant, M Van Rees… - Journal of Biological …, 2002 - ASBMB
CCAAT/enhancer-binding proteins (C/EBP) are critical determinants for cellular
differentiation and cell type-specific gene expression. Their functional roles in osteoblast
development have not been determined. We addressed a key component of the
mechanisms by which C/EBP factors regulate transcription of a tissue-specific gene during
osteoblast differentiation. Expression of both C/EBPβ and C/EBPδ increases from the growth
to maturation developmental stages and, like the bone-specific osteocalcin (OC) gene, is …
differentiation and cell type-specific gene expression. Their functional roles in osteoblast
development have not been determined. We addressed a key component of the
mechanisms by which C/EBP factors regulate transcription of a tissue-specific gene during
osteoblast differentiation. Expression of both C/EBPβ and C/EBPδ increases from the growth
to maturation developmental stages and, like the bone-specific osteocalcin (OC) gene, is …