Nicotine activates cell-signaling pathways through muscle-type and neuronal nicotinic acetylcholine receptors in non-small cell lung cancer cells
DL Carlisle, X Liu, TM Hopkins, MC Swick… - Pulmonary …, 2007 - Elsevier
Nicotinic acetylcholine receptors (nAChR) are expressed on non-neuronal cell types,
including normal bronchial epithelial cells, and nicotine has been reported to cause Akt
activation in cultured normal airway cells. This study documents mRNA and protein
expression of subunits known to form a muscle-type nAChR in non-small cell lung cancer
(NSCLC) cell lines. In one NSCLC examined, mRNA and protein for a heteropentamer
neuronal-type α3β2 nAChR was detected in addition to a muscle-type receptor. Protein for …
including normal bronchial epithelial cells, and nicotine has been reported to cause Akt
activation in cultured normal airway cells. This study documents mRNA and protein
expression of subunits known to form a muscle-type nAChR in non-small cell lung cancer
(NSCLC) cell lines. In one NSCLC examined, mRNA and protein for a heteropentamer
neuronal-type α3β2 nAChR was detected in addition to a muscle-type receptor. Protein for …