[HTML][HTML] The endoplasmic reticulum-resident heat shock protein Gp96 activates dendritic cells via the Toll-like receptor 2/4 pathway
RM Vabulas, S Braedel, N Hilf, H Singh-Jasuja… - Journal of Biological …, 2002 - ASBMB
The heat shock protein Gp96 has been shown to induce specific immune responses. On one
hand, this phenomenon is based on the specific interaction with CD91 that mediates
endocytosis and results in major histocompatibility complex class I-restricted representation
of the Gp96-associated peptides. On the other hand, Gp96 induces activation of professional
antigen-presenting cells, resulting in the production of pro-inflammatory cytokines and up-
regulation of costimulatory molecules by unknown mechanisms. In this study, we have …
hand, this phenomenon is based on the specific interaction with CD91 that mediates
endocytosis and results in major histocompatibility complex class I-restricted representation
of the Gp96-associated peptides. On the other hand, Gp96 induces activation of professional
antigen-presenting cells, resulting in the production of pro-inflammatory cytokines and up-
regulation of costimulatory molecules by unknown mechanisms. In this study, we have …