Opposing functions of GDNF and NGF in the development of cholinergic and noradrenergic sympathetic neurons

C Brodski, A Schaubmar, G Dechant - Molecular and Cellular …, 2002 - Elsevier
We identified a population of mature sympathetic neurons in which Ret, the receptor for glial
cell line-derived neurotrophic factor (GDNF), is coexpressed with the neurotrophin-3 (NT3)
receptor TrkC and choline acetyltransferase. In a complementary population the nerve
growth factor receptor TrkA is coexpressed with the norepinephrine transporter. In
accordance with these in vivo results, GDNF and neurturin promote the expression of
cholinergic marker genes in sympathetic chain explants, similar to NT3 and ciliary …