Centrosome aberrations: cause or consequence of cancer progression?
EA Nigg - Nature Reviews Cancer, 2002 - nature.com
Nature Reviews Cancer, 2002•nature.com
Many human tumours show centrosome aberrations, indicating an underlying deregulation
of centrosome structure, duplication or segregation. Centrosomes organize microtubule
arrays throughout the cell cycle, thereby influencing both tissue architecture and the
accuracy of chromosome segregation. But what are the origins of centrosomal abnormalities
in tumours, and what impact do they have on the generation of invasive, genetically
unbalanced cells during cancer progression?
of centrosome structure, duplication or segregation. Centrosomes organize microtubule
arrays throughout the cell cycle, thereby influencing both tissue architecture and the
accuracy of chromosome segregation. But what are the origins of centrosomal abnormalities
in tumours, and what impact do they have on the generation of invasive, genetically
unbalanced cells during cancer progression?
Abstract
Many human tumours show centrosome aberrations, indicating an underlying deregulation of centrosome structure, duplication or segregation. Centrosomes organize microtubule arrays throughout the cell cycle, thereby influencing both tissue architecture and the accuracy of chromosome segregation. But what are the origins of centrosomal abnormalities in tumours, and what impact do they have on the generation of invasive, genetically unbalanced cells during cancer progression?
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