[HTML][HTML] Cell cycle-dependent expression of centrosomal ninein-like protein in human cells is regulated by the anaphase-promoting complex
Y Wang, Q Zhan - Journal of Biological Chemistry, 2007 - ASBMB
The recently identified centrosome protein Nlp (ninein-like protein) is a key regulator in
centrosome maturation, which contributes to chromosome segregation and cytokinesis.
However, the mechanism (s) controlling Nlp expression remains largely unknown. Here we
have shown that Nlp expression is cell cycle-dependent with a peak at G 2/M transition in
human cells. Nlp is a short-lived protein and degraded by the proteasome via the anaphase-
promoting cyclosome complex (APC/c) pathway. It interacts with the APC/c through the …
centrosome maturation, which contributes to chromosome segregation and cytokinesis.
However, the mechanism (s) controlling Nlp expression remains largely unknown. Here we
have shown that Nlp expression is cell cycle-dependent with a peak at G 2/M transition in
human cells. Nlp is a short-lived protein and degraded by the proteasome via the anaphase-
promoting cyclosome complex (APC/c) pathway. It interacts with the APC/c through the …