[HTML][HTML] Gadd45a interacts with aurora-A and inhibits its kinase activity
S Shao, Y Wang, S Jin, Y Song, X Wang, W Fan… - Journal of biological …, 2006 - ASBMB
Centrosome stability is required for successful mitosis in mammalian cells. Amplification of
the centrosome leads to chromosomal missegregation and generation of aneuploidy, which
are closely associated with cell transformation and tumorigenesis (Doxsey, SJ (2001) Nat.
Cell Biol. 3, E105-E108; Hinchcliffe, EH, and Sluder, G.(2001) Genes Dev. 15, 1167-1181;
Pihan, GA, Purohit, A., Wallace, J., Malhotra, R., Liotta, L., and Doxsey, SJ (2001) Cancer
Res. 61, 2212-2219). However, there are currently limited insights into mechanism (s) for …
the centrosome leads to chromosomal missegregation and generation of aneuploidy, which
are closely associated with cell transformation and tumorigenesis (Doxsey, SJ (2001) Nat.
Cell Biol. 3, E105-E108; Hinchcliffe, EH, and Sluder, G.(2001) Genes Dev. 15, 1167-1181;
Pihan, GA, Purohit, A., Wallace, J., Malhotra, R., Liotta, L., and Doxsey, SJ (2001) Cancer
Res. 61, 2212-2219). However, there are currently limited insights into mechanism (s) for …