Effects of isoflurane on coronary blood flow velocity in young, old and ApoE−/− mice measured by Doppler ultrasound
CJ Hartley, AK Reddy, S Madala, LH Michael… - Ultrasound in medicine …, 2007 - Elsevier
The commonly used anesthetic agent isoflurane (ISO) is a potent coronary vasodilator that
could potentially be used in the assessment of coronary reserve, but its effects on coronary
blood flow in mice are unknown. Coronary reserve is reduced by age, coronary artery
disease and other cardiac pathologies in man, and some of these conditions can now be
modeled in mice. Accordingly, we used Doppler ultrasound to measure coronary flow
velocity in mice anesthetized with low (1%) and high (2.5%) levels of ISO to generate …
could potentially be used in the assessment of coronary reserve, but its effects on coronary
blood flow in mice are unknown. Coronary reserve is reduced by age, coronary artery
disease and other cardiac pathologies in man, and some of these conditions can now be
modeled in mice. Accordingly, we used Doppler ultrasound to measure coronary flow
velocity in mice anesthetized with low (1%) and high (2.5%) levels of ISO to generate …