Cutting edge: human CD4+ CD25+ T cells restrain the maturation and antigen-presenting function of dendritic cells
N Misra, J Bayry, S Lacroix-Desmazes… - The Journal of …, 2004 - journals.aai.org
The Journal of Immunology, 2004•journals.aai.org
The characteristics and functions of CD4+ CD25+ regulatory cells have been well defined in
murine and human systems. However, the interaction between CD4+ CD25+ T cells and
dendritic cells (DC) remains unclear. In this study, we examined the effect of human CD4+
CD25+ T cells on maturation and function of monocyte-derived DC. We show that regulatory
T cells render the DC inefficient as APCs despite prestimulation with CD40 ligand. This
effect was marginally reverted by neutralizing Abs to TGF-β. There was an increased IL-10 …
murine and human systems. However, the interaction between CD4+ CD25+ T cells and
dendritic cells (DC) remains unclear. In this study, we examined the effect of human CD4+
CD25+ T cells on maturation and function of monocyte-derived DC. We show that regulatory
T cells render the DC inefficient as APCs despite prestimulation with CD40 ligand. This
effect was marginally reverted by neutralizing Abs to TGF-β. There was an increased IL-10 …
Abstract
The characteristics and functions of CD4+ CD25+ regulatory cells have been well defined in murine and human systems. However, the interaction between CD4+ CD25+ T cells and dendritic cells (DC) remains unclear. In this study, we examined the effect of human CD4+ CD25+ T cells on maturation and function of monocyte-derived DC. We show that regulatory T cells render the DC inefficient as APCs despite prestimulation with CD40 ligand. This effect was marginally reverted by neutralizing Abs to TGF-β. There was an increased IL-10 secretion and reduced expression of costimulatory molecules in DC. Thus, in addition to direct suppressor effect on CD4+ T cells, regulatory T cells may modulate the immune response through DC.
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