[HTML][HTML] MyD88 adapter-like (Mal)/TIRAP interaction with TRAF6 is critical for TLR2-and TLR4-mediated NF-κB proinflammatory responses
B Verstak, K Nagpal, SP Bottomley… - Journal of biological …, 2009 - ASBMB
Toll/interleukin-1 (TIR) receptor-containing adapters are critical in orchestrating the different
signal transduction pathways following Toll-like receptor (TLR) activation. MyD88 adapter-
like (Mal), also termed TIRAP, is involved in bridging MyD88 to the receptor complex for TLR-
2 and TLR4 signaling in response to bacterial infection. We have previously reported an
interaction between Mal and tumor necrosis factor receptor-associated factor 6 (TRAF6) via
a TRAF6-binding motif, the disruption of which inhibited TLR-mediated NF-κB-luciferase …
signal transduction pathways following Toll-like receptor (TLR) activation. MyD88 adapter-
like (Mal), also termed TIRAP, is involved in bridging MyD88 to the receptor complex for TLR-
2 and TLR4 signaling in response to bacterial infection. We have previously reported an
interaction between Mal and tumor necrosis factor receptor-associated factor 6 (TRAF6) via
a TRAF6-binding motif, the disruption of which inhibited TLR-mediated NF-κB-luciferase …