Induction of circulating tumor-reactive CD8+ T cells after vaccination of melanoma patients with the gp100209-2M peptide
SL Meijer, A Dols, SM Jensen, HM Hu… - Journal of …, 2007 - journals.lww.com
Patients with stage I-III melanoma were vaccinated with the modified HLA-A2–binding
gp100 209-2M-peptide after complete surgical resection of their primary lesion and sentinel
node biopsy. Cytoplasmic interferon-γ production by freshly thawed peripheral blood
mononuclear cells (direct ex vivo analysis) or by peripheral blood mononuclear cells
subjected to 1 cycle of in vitro sensitization with peptide, interleukin-2, and interleukin-15
was measured following restimulation with the modified and native gp100 peptides, and …
gp100 209-2M-peptide after complete surgical resection of their primary lesion and sentinel
node biopsy. Cytoplasmic interferon-γ production by freshly thawed peripheral blood
mononuclear cells (direct ex vivo analysis) or by peripheral blood mononuclear cells
subjected to 1 cycle of in vitro sensitization with peptide, interleukin-2, and interleukin-15
was measured following restimulation with the modified and native gp100 peptides, and …