The human homolog T of the mouse T (Brachyury) gene; gene structure, cDNA sequence, and assignment to chromosome 6q27.

YH Edwards, W Putt, KM Lekoape, D Stott… - Genome …, 1996 - genome.cshlp.org
YH Edwards, W Putt, KM Lekoape, D Stott, M Fox, DA Hopkinson, J Sowden
Genome research, 1996genome.cshlp.org
We have cloned the human gene encoding the transcription factor T. T protein is vital for the
formation of posterior mesoderm and axial development in all vertebrates. Brachyury mutant
mice, which lack T protein, die in utero with abnormal notochord, posterior somites, and
allantois. We have identified human T genomic clones and derived the mRNA sequence
and gene structure. There is 91% amino acid identity between human and mouse T proteins
overall and complete identity across 77 amino acids of the T-box motif within the DNA …
We have cloned the human gene encoding the transcription factor T. T protein is vital for the formation of posterior mesoderm and axial development in all vertebrates. Brachyury mutant mice, which lack T protein, die in utero with abnormal notochord, posterior somites, and allantois. We have identified human T genomic clones and derived the mRNA sequence and gene structure. There is 91% amino acid identity between human and mouse T proteins overall and complete identity across 77 amino acids of the T-box motif within the DNA-binding domain. Human T expression is very similar to that found for T in other vertebrate species and is confined to cells derived from the notochord. The human T gene maps to chromosome 6q27 and is only the second human member of the T-box gene family to be described.
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