Cloning of the T gene required in mesoderm formation in the mouse
BG Herrmann, S Labeit, A Poustka, TR King, H Lehrach - Nature, 1990 - nature.com
BG Herrmann, S Labeit, A Poustka, TR King, H Lehrach
Nature, 1990•nature.comThe murine developmental mutation T identifies an essential gene in mesoderm formation.
Embryos lacking normal gene activity fail to form the notochord, the entire posterior region
and the allan-tois, and die at about 10 days of gestation. We have isolated the T gene using
a combination of molecular and genetic techniques, thus making molecular tools available
to study processes underlying mesoderm formation in the mouse.
Embryos lacking normal gene activity fail to form the notochord, the entire posterior region
and the allan-tois, and die at about 10 days of gestation. We have isolated the T gene using
a combination of molecular and genetic techniques, thus making molecular tools available
to study processes underlying mesoderm formation in the mouse.
Abstract
The murine developmental mutation T identifies an essential gene in mesoderm formation. Embryos lacking normal gene activity fail to form the notochord, the entire posterior region and the allan-tois, and die at about 10 days of gestation. We have isolated the T gene using a combination of molecular and genetic techniques, thus making molecular tools available to study processes underlying mesoderm formation in the mouse.
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