Since its isolation exactly a decade ago, B‐Myb has intrigued a growing number of scientists interested in understanding the mechanisms of cell proliferation. In many aspects the B‐Myb story resembles that of a fashionable transcription factor involved in cell cycle control: E2F‐1. Similar to E2F‐1, B‐Myb is a transcription factor whose expression is regulated at the G1/S border of the cell cycle. Given the ubiquitous expression of B‐Myb within different cell types, its link with the cell cycle, and augmented expression in transformed cells, studies are in progress to define the potential role of B‐Myb in human cancer. The purpose of this review is not to provide an extensive background to the B‐Myb field but rather to describe the latest developments. A comprehensive outline of B‐Myb structure and function can be found in the review by Saville and Watson (1998a, Adv. Cancer Res., 72:109–140). J. Cell. Physiol. 179:245–250, 1999. © 1999 Wiley‐Liss, Inc.