Myb: a transcriptional activator linking proliferation and differentiation in hematopoietic cells
T Graf - Current opinion in genetics & development, 1992 - Elsevier
Current opinion in genetics & development, 1992•Elsevier
Myb is a transcriptional activator protein with repeated helix-turn-helix DNA-binding motifs
distantly related to the homeodomain. In hematopoiesis, c-myb appears to control both cell
proliferation and differentiation. The mechanisms by which the leukemogenic potential of c-
Myb is activated are complex and involve truncations, point mutations, and fusion or
coexpression with other proteins.
distantly related to the homeodomain. In hematopoiesis, c-myb appears to control both cell
proliferation and differentiation. The mechanisms by which the leukemogenic potential of c-
Myb is activated are complex and involve truncations, point mutations, and fusion or
coexpression with other proteins.
Myb is a transcriptional activator protein with repeated helix-turn-helix DNA-binding motifs distantly related to the homeodomain. In hematopoiesis, c-myb appears to control both cell proliferation and differentiation. The mechanisms by which the leukemogenic potential of c-Myb is activated are complex and involve truncations, point mutations, and fusion or coexpression with other proteins.
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