[HTML][HTML] Interferon regulatory factor 1 is an essential and direct transcriptional activator for interferon γ-induced RANTES/CCl5 expression in macrophages
J Liu, X Guan, X Ma - Journal of Biological Chemistry, 2005 - ASBMB
Interferon regulatory factor 1 (IRF-1) is an important transcription factor in interferon γ (IFNγ)-
mediated signaling in the development and function of NK cells and cytotoxic T lymphocytes.
RANTES (regulated on activation normal T cell expressed and secreted; CCL5) is a member
of the CC chemokine family of proteins, which is strongly chemoattractant for several
important immune cell types in host defense against infectious agents and cancer. However,
the role of IFNγ and IRF-1 in the regulation of RANTES gene expression and their operative …
mediated signaling in the development and function of NK cells and cytotoxic T lymphocytes.
RANTES (regulated on activation normal T cell expressed and secreted; CCL5) is a member
of the CC chemokine family of proteins, which is strongly chemoattractant for several
important immune cell types in host defense against infectious agents and cancer. However,
the role of IFNγ and IRF-1 in the regulation of RANTES gene expression and their operative …