Impaired T cell function in RANTES-deficient mice

Y Makino, DN Cook, O Smithies, OY Hwang… - Clinical …, 2002 - Elsevier
The chemokine RANTES is a chemoattractant for monocytes and T cells and is postulated to
participate in many aspects of the immune response. To evaluate the biological roles of
RANTES in vivo, we generated RANTES-deficient (−/−) mice and characterized their T cell
function. In cutaneous delayed-type hypersensitivity assays, a 50% reduction in ear and
footpad swelling was seen in−/− mice compared to+/+ mice. In vitro, polyclonal and antigen-
specific T cell proliferation was decreased. Quantitative analysis using the fluorescent dye …