Short‐term treatment using insulin‐like growth factor‐1 (IGF‐1) improves life expectancy of the delta‐sarcoglycan deficient hamster
A Serose, A Salmon, MY Fiszman… - The Journal of Gene …, 2006 - Wiley Online Library
A Serose, A Salmon, MY Fiszman, Y Fromes
The Journal of Gene Medicine: A cross‐disciplinary journal for …, 2006•Wiley Online LibraryBackground The hamster strain CHF147 presents a progressive dilated cardiomyopathy
(DCM) due to a large deletion of the delta‐sarcoglycan gene that leads to heart failure. This
cardiomyopathy induces premature death. We have previously shown that a short‐term
treatment using IGF‐1 preserves cardiac structure and improves function of the CHF147
hamster. Methods In the current study, we measured long‐term effects of short‐term
treatment with recombinant human IGF‐1 (rhIGF‐1) in CHF147 hamsters. CHF147 hamsters …
(DCM) due to a large deletion of the delta‐sarcoglycan gene that leads to heart failure. This
cardiomyopathy induces premature death. We have previously shown that a short‐term
treatment using IGF‐1 preserves cardiac structure and improves function of the CHF147
hamster. Methods In the current study, we measured long‐term effects of short‐term
treatment with recombinant human IGF‐1 (rhIGF‐1) in CHF147 hamsters. CHF147 hamsters …
Background
The hamster strain CHF147 presents a progressive dilated cardiomyopathy (DCM) due to a large deletion of the delta‐sarcoglycan gene that leads to heart failure. This cardiomyopathy induces premature death. We have previously shown that a short‐term treatment using IGF‐1 preserves cardiac structure and improves function of the CHF147 hamster.
Methods
In the current study, we measured long‐term effects of short‐term treatment with recombinant human IGF‐1 (rhIGF‐1) in CHF147 hamsters. CHF147 hamsters (7–8 months old) were implanted under the skin with an osmotic pump filled either with saline or with recombinant human IGF‐1 at a total dose of 25 µg. The osmotic pump allowed a continuous delivery of the protein for a mean duration of 19 days.
Results
We observed a significant increase in overall survival, as well as preservation of cardiac function, in the rhIGF‐1‐treated group. At the time of death, hearts of treated animals did not present any macroscopical or histological differences compared to those of sham hamsters. These results show that rhIGF‐1 treatment slows down the evolution of the DCM in the CHF147 hamster. Moreover, the low dose treatment did not increase IGF‐1 serum levels.
Conclusions
This study is the first one reporting beneficial effects of IGF‐1 treatment on survival of an animal model presenting DCM. Our results raise hopes for a new therapeutic approach of this pathology. Copyright © 2006 John Wiley & Sons, Ltd.
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