[HTML][HTML] Activation of the calcium-permeable cation channel CD20 by α subunits of the Gi protein
M Kanzaki, MA Lindorfer, JC Garrison… - Journal of Biological …, 1997 - ASBMB
When the calcium-permeable cation channel CD20 is expressed in Balb/c 3T3 cells, it is
activated by insulin-like growth factor-I (IGF-I) via the IGF-I receptor (Kanzaki, M., Nie, L.,
Shibata, H., and Kojima, I.(1997) J. Biol. Chem. 272, 4964–4969). The present study was
conducted to investigate the role of G proteins in the regulation of the CD20 channel. In the
excised patch clamp mode, activation of the CD20 channel by IGF-I required GTP, Mg 2+,
and ATP in the bath solution, and removal of either GTP or ATP attenuated the activation …
activated by insulin-like growth factor-I (IGF-I) via the IGF-I receptor (Kanzaki, M., Nie, L.,
Shibata, H., and Kojima, I.(1997) J. Biol. Chem. 272, 4964–4969). The present study was
conducted to investigate the role of G proteins in the regulation of the CD20 channel. In the
excised patch clamp mode, activation of the CD20 channel by IGF-I required GTP, Mg 2+,
and ATP in the bath solution, and removal of either GTP or ATP attenuated the activation …