[HTML][HTML] Development of TLR9 agonists for cancer therapy

AM Krieg - The Journal of clinical investigation, 2007 - Am Soc Clin Investig
The Journal of clinical investigation, 2007Am Soc Clin Investig
In vertebrates, the TLRs are a family of specialized immune receptors that induce protective
immune responses when they detect highly conserved pathogen-expressed molecules.
Synthetic agonists for several TLRs, including TLR3, TLR4, TLR7, TLR8, and TLR9, have
been or are being developed for the treatment of cancer. TLR9 detects the unmethylated
CpG dinucleotides prevalent in bacterial and viral DNA but not in vertebrate genomes. As
discussed in this Review, short synthetic oligodeoxynucleotides containing these immune …
In vertebrates, the TLRs are a family of specialized immune receptors that induce protective immune responses when they detect highly conserved pathogen-expressed molecules. Synthetic agonists for several TLRs, including TLR3, TLR4, TLR7, TLR8, and TLR9, have been or are being developed for the treatment of cancer. TLR9 detects the unmethylated CpG dinucleotides prevalent in bacterial and viral DNA but not in vertebrate genomes. As discussed in this Review, short synthetic oligodeoxynucleotides containing these immune stimulatory CpG motifs activate TLR9 in vitro and in vivo, inducing innate and adaptive immunity, and are currently being tested in multiple phase II and phase III human clinical trials as adjuvants to cancer vaccines and in combination with conventional chemotherapy and other therapies.
The Journal of Clinical Investigation