The hypoxic proteome is influenced by gene-specific changes in mRNA translation
M Koritzinsky, R Seigneuric, MG Magagnin… - Radiotherapy and …, 2005 - Elsevier
BACKGROUND AND PURPOSE: Hypoxia causes a rapid reduction in mRNA translation
efficiency. This inhibition does not affect all mRNA species to the same extent and can
therefore contribute significantly to hypoxia-induced differential protein expression. Our aim
in this study was to characterize changes in gene expression during acute hypoxia and
evaluate the contribution of regulation via mRNA translation on these changes. For each
gene, the contribution of changes in mRNA abundance versus mRNA translation was …
efficiency. This inhibition does not affect all mRNA species to the same extent and can
therefore contribute significantly to hypoxia-induced differential protein expression. Our aim
in this study was to characterize changes in gene expression during acute hypoxia and
evaluate the contribution of regulation via mRNA translation on these changes. For each
gene, the contribution of changes in mRNA abundance versus mRNA translation was …