Renal interstitial fibrosis is characterized by increased proliferation of fibroblasts and
excessive accumulation of extracellular matrix. Mast cell tryptase has been implicated in the
development of tissue fibrosis in skin and lungs. However, the significance of mast cell
tryptase in human renal diseases has not been investigated. The potential role of mast cell-
derived tryptase in the development of renal fibrosis was studied using
immunohistochemical techniques and cultured human renal fibroblast cell lines …