[HTML][HTML] The molecular adapter SLP-76 relays signals from platelet integrin αIIbβ3 to the actin cytoskeleton
A Obergfell, BA Judd, MA del Pozo… - Journal of Biological …, 2001 - ASBMB
Platelet adhesion to fibrinogen through integrin α IIb β 3 triggers actin rearrangements and
cell spreading. Mice deficient in the SLP-76 adapter molecule bleed excessively, and their
platelets spread poorly on fibrinogen. Here we used human platelets and a Chinese
hamster ovary (CHO) cell expression system to better define the role of SLP-76 in α IIb β 3
signaling. CHO cell adhesion to fibrinogen required α IIb β 3 and stimulated tyrosine
phosphorylation of SLP-76. SLP-76 phosphorylation required coexpression of Syk tyrosine …
cell spreading. Mice deficient in the SLP-76 adapter molecule bleed excessively, and their
platelets spread poorly on fibrinogen. Here we used human platelets and a Chinese
hamster ovary (CHO) cell expression system to better define the role of SLP-76 in α IIb β 3
signaling. CHO cell adhesion to fibrinogen required α IIb β 3 and stimulated tyrosine
phosphorylation of SLP-76. SLP-76 phosphorylation required coexpression of Syk tyrosine …