[HTML][HTML] Kinetic regulation of β3 integrin tyrosine phosphorylation
SD Blystone - Journal of Biological Chemistry, 2002 - ASBMB
Tyrosine phosphorylation of β 3 integrins is a permissive stage in the activation of α IIb β 3
and α v β 3 in platelets and leukocytes, respectively. In this study we demonstrated direct
phosphorylation of β 3 integrins as a result of interaction with soluble monomeric ligand, and
we characterized the differential kinetics of β 3 phosphorylation as a consequence of α
subunit pairing. We found that β 3 phosphorylation is initiated by RGD peptide binding in a
dose-dependent and saturable fashion with α IIb β 3 becoming phosphorylated and …
and α v β 3 in platelets and leukocytes, respectively. In this study we demonstrated direct
phosphorylation of β 3 integrins as a result of interaction with soluble monomeric ligand, and
we characterized the differential kinetics of β 3 phosphorylation as a consequence of α
subunit pairing. We found that β 3 phosphorylation is initiated by RGD peptide binding in a
dose-dependent and saturable fashion with α IIb β 3 becoming phosphorylated and …