Thrombus formation, including platelet adhesion, activation, secretion and aggregation as
well as tissue factor-initiated thrombin generation and fibrin formation, has been studied in
the past using in vitro systems, often with isolated components. Given the complexity of
hemostasis and thrombosis, many of the concepts that have been developed to explain
these processes are being revisited by studying thrombus formation in live animals using
intravital microscopy and genetically altered mice. Although much of the dogma that has …