[HTML][HTML] The adaptor molecule Lnk negatively regulates tumor necrosis factor-α-dependent VCAM-1 expression in endothelial cells through inhibition of the ERK1 and …
J Fitau, G Boulday, F Coulon, T Quillard… - Journal of biological …, 2006 - ASBMB
Lnk, with APS and SH2-B (Src homology 2-B), belongs to a family of SH2-containing
proteins with potential adaptor functions. Lnk regulates growth factor and cytokine receptor-
mediated pathways implicated in lymphoid, myeloid, and platelet homeostasis. We have
previously shown that Lnk is expressed and up-regulated in vascular endothelial cells (ECs)
in response to tumor necrosis factor-α (TNFα). In this study, we have shown that, in ECs, Lnk
down-regulates the expression, at both mRNA and protein levels, of the proinflammatory …
proteins with potential adaptor functions. Lnk regulates growth factor and cytokine receptor-
mediated pathways implicated in lymphoid, myeloid, and platelet homeostasis. We have
previously shown that Lnk is expressed and up-regulated in vascular endothelial cells (ECs)
in response to tumor necrosis factor-α (TNFα). In this study, we have shown that, in ECs, Lnk
down-regulates the expression, at both mRNA and protein levels, of the proinflammatory …