[HTML][HTML] Inhibition of carnitine palmitoyltransferase I augments sphingolipid synthesis and palmitate-induced apoptosis
MB Paumen, Y Ishida, M Muramatsu… - Journal of Biological …, 1997 - ASBMB
To identify cell death-induced genes, we employed a subtractive hybridization approach and
isolated a cDNA encoding a mouse homolog of carnitine palmitoyltransferase I (CPT I), an
enzyme that resides at the outer mitochondrial membrane and facilitates passage of long-
chain fatty acids into mitochondria for β-oxidation. Induced expression of CPT I mRNA was
observed upon programmed cell death in the murine hematopoietic cell lines LyD9 and
WEHI-231. To elucidate the role of CPT I in programmed cell death, we examined the effects …
isolated a cDNA encoding a mouse homolog of carnitine palmitoyltransferase I (CPT I), an
enzyme that resides at the outer mitochondrial membrane and facilitates passage of long-
chain fatty acids into mitochondria for β-oxidation. Induced expression of CPT I mRNA was
observed upon programmed cell death in the murine hematopoietic cell lines LyD9 and
WEHI-231. To elucidate the role of CPT I in programmed cell death, we examined the effects …