IL-21 enhances dendritic cell ability to induce interferon-γ production by natural killer T cells
M Maeda, Y Yanagawa, K Iwabuchi, K Minami… - Immunobiology, 2007 - Elsevier
Interleukin (IL)-21 shows pleiotropic effects on the proliferation, differentiation, and effector
functions of leukocytes. However, the influence of IL-21 on dendritic cell (DC) activation of
natural killer T (NKT) cells has not yet been elucidated. In the present study, we examined
the effect of IL-21 on murine myeloid DC ability to induce NKT cell production of interferon-γ
(IFN-γ) and IL-4. Pretreatment of DCs with IL-21 and α-galactosylceramide (α-GalCer), an
NKT cell-specific ligand, resulted in the enhanced ability of the DCs to induce NKT cell …
functions of leukocytes. However, the influence of IL-21 on dendritic cell (DC) activation of
natural killer T (NKT) cells has not yet been elucidated. In the present study, we examined
the effect of IL-21 on murine myeloid DC ability to induce NKT cell production of interferon-γ
(IFN-γ) and IL-4. Pretreatment of DCs with IL-21 and α-galactosylceramide (α-GalCer), an
NKT cell-specific ligand, resulted in the enhanced ability of the DCs to induce NKT cell …