[HTML][HTML] Deletions of chromosome 8p and loss of sFRP1 expression are progression markers of papillary bladder cancer
R Stoehr, C Wissmann, H Suzuki, R Knuechel… - Laboratory …, 2004 - Elsevier
Many molecular alterations are known to occur in urothelial carcinoma of the bladder, but
their significance for tumor progression is poorly understood. Deletions of chromosome 8p
are frequently found in several tumor types and are often associated with progressive
disease. In all, 99 bladder tumors were screened for deletions at 8p using loss of
heterozygosity (LOH) and multicolor fluorescence in situ hybridization FISH analyses. Allelic
loss on chromosome 8p in at least one marker was found in 25/99 (25%) tumors. There was …
their significance for tumor progression is poorly understood. Deletions of chromosome 8p
are frequently found in several tumor types and are often associated with progressive
disease. In all, 99 bladder tumors were screened for deletions at 8p using loss of
heterozygosity (LOH) and multicolor fluorescence in situ hybridization FISH analyses. Allelic
loss on chromosome 8p in at least one marker was found in 25/99 (25%) tumors. There was …