Complex CGH alterations on chromosome arm 8p at candidate tumor suppressor gene loci in breast cancer cell lines
DJ Venter, SJ Ramus, FMA Hammet, M de Silva… - Cancer genetics and …, 2005 - Elsevier
Loss of genetic material from chromosome arm 8p occurs frequently in human breast
carcinomas, consistent with this region of the genome harboring one or more tumor
suppressor genes (TSGs). We used the complementary techniques of microsatellite-based
LOH, high-density FISH, and conventional CGH on 6 breast cancer cell lines (MCF7,
SKBR3, T47D, MDA MB453, BT549, and BT474) to investigate the molecular cytogenetic
changes occurring on chromosome 8 during tumorigenesis, with particular emphasis on 6 …
carcinomas, consistent with this region of the genome harboring one or more tumor
suppressor genes (TSGs). We used the complementary techniques of microsatellite-based
LOH, high-density FISH, and conventional CGH on 6 breast cancer cell lines (MCF7,
SKBR3, T47D, MDA MB453, BT549, and BT474) to investigate the molecular cytogenetic
changes occurring on chromosome 8 during tumorigenesis, with particular emphasis on 6 …