[HTML][HTML] Functional nanofiber scaffolds with different spacers modulate adhesion and expansion of cryopreserved umbilical cord blood hematopoietic stem/progenitor …

KN Chua, C Chai, PC Lee, S Ramakrishna… - Experimental …, 2007 - Elsevier
OBJECTIVE: Nanofiber scaffolds with amino groups conjugated to fiber surface through
different spacers (ethylene, butylenes, and hexylene groups, respectively) were prepared
and the effect of spacer length on adhesion and expansion of umbilical cord blood
hematopoietic stem/progenitor cells (HSPCs) was investigated. MATERIALS AND
METHODS: Electrospun polymer nanofiber scaffolds were functionalized with poly (acrylic
acid) grafting, followed by conjugation of amino groups with different spacers. HSPCs were …