Differentiation of the mouse hepatic primordium. II. Extrinsic origin of the haemopoietic cell line

E Houssaint - Cell differentiation, 1981 - Elsevier
The whole hepatic primordium (endoderm+ mesenchyme of the septum transversum) was
isolated from mouse embryos at various developmental stages, from 8 to 10 days of
gestation, and was either grafted into chick or quail embryo or cultivated in vitro.
Haemopoiesis developed only if the liver rudiment had been explanted after the 28-to 30-
somite stage, but not if explanted prior to this stage, despite normal differentiation of the
hepatocytes. However, when the liver rudiment, isolated before the 28-somite stage in in …