Time to give up on a single explanation for autism

F Happé, A Ronald, R Plomin - Nature neuroscience, 2006 - nature.com
Nature neuroscience, 2006nature.com
We argue that there will be no single (genetic or cognitive) cause for the diverse symptoms
defining autism. We present recent evidence of behavioral fractionation of social impairment,
communication difficulties and rigid and repetitive behaviors. Twin data suggest largely
nonoverlapping genes acting on each of these traits. At the cognitive level, too, attempts at a
single explanation for the symptoms of autism have failed. Implications for research and
treatment are discussed.
Abstract
We argue that there will be no single (genetic or cognitive) cause for the diverse symptoms defining autism. We present recent evidence of behavioral fractionation of social impairment, communication difficulties and rigid and repetitive behaviors. Twin data suggest largely nonoverlapping genes acting on each of these traits. At the cognitive level, too, attempts at a single explanation for the symptoms of autism have failed. Implications for research and treatment are discussed.
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