Differentiation and functional analysis of human TH17 cells
S Burgler, N Ouaked, C Bassin, TM Basinski… - Journal of Allergy and …, 2009 - Elsevier
BACKGROUND: TH17 cells are of pathologic relevance in autoimmune disorders and
presumably also in allergy and asthma. Regulatory T (Treg) cells, in contrast, suppress
inflammatory and allergen-driven responses. Despite these disparate functions, both T-cell
subsets have been shown to be dependent on TGF-β for their development. OBJECTIVE:
The aim of the study was to analyze the differentiation and function of human TH17 cells in
comparison with other TH cell subsets. METHODS: Naive human CD4+ T cells were …
presumably also in allergy and asthma. Regulatory T (Treg) cells, in contrast, suppress
inflammatory and allergen-driven responses. Despite these disparate functions, both T-cell
subsets have been shown to be dependent on TGF-β for their development. OBJECTIVE:
The aim of the study was to analyze the differentiation and function of human TH17 cells in
comparison with other TH cell subsets. METHODS: Naive human CD4+ T cells were …