Chronic innate immune activation as a cause of HIV-1 immunopathogenesis
A Boasso, GM Shearer - Clinical immunology, 2008 - Elsevier
Human immunodeficiency virus (HIV)-1 infection causes progressive impairment of the
immune system in humans, characterized by depletion of CD4 T cells and loss of T cell
function. Increased markers of T cell activation and lymphoid hyperplasia suggest that
chronic T cell activation persists in immunocompromised hosts, and contributes to the
exhaustion of immune functions. Here we propose a revision of this hypothesis, in which we
suggest that chronic activation of innate immunity may negatively affect adaptive T cell …
immune system in humans, characterized by depletion of CD4 T cells and loss of T cell
function. Increased markers of T cell activation and lymphoid hyperplasia suggest that
chronic T cell activation persists in immunocompromised hosts, and contributes to the
exhaustion of immune functions. Here we propose a revision of this hypothesis, in which we
suggest that chronic activation of innate immunity may negatively affect adaptive T cell …