[HTML][HTML] Smurf1 inhibits osteoblast differentiation and bone formation in vitro and in vivo
M Zhao, M Qiao, SE Harris, BO Oyajobi… - Journal of Biological …, 2004 - ASBMB
Bone morphogenetic proteins (BMPs) are required for normal postnatal bone formation and
osteoblast differentiation. There is evidence from recent studies that BMP signaling in
osteoblasts is controlled by an ubiquitin-proteasome regulatory mechanism involving a
cascade of enzymatic reactions. The specificity of protein ubiquitination is determined by E3
ubiquitin ligases, which play a crucial role in defining substrate specificity and subsequent
protein degradation by 26S proteasomes. We have examined the role of the E3 ubiquitin …
osteoblast differentiation. There is evidence from recent studies that BMP signaling in
osteoblasts is controlled by an ubiquitin-proteasome regulatory mechanism involving a
cascade of enzymatic reactions. The specificity of protein ubiquitination is determined by E3
ubiquitin ligases, which play a crucial role in defining substrate specificity and subsequent
protein degradation by 26S proteasomes. We have examined the role of the E3 ubiquitin …