[HTML][HTML] Genetic inhibition or activation of JNK1/2 protects the myocardium from ischemia-reperfusion-induced cell death in vivo
RA Kaiser, Q Liang, O Bueno, Y Huang… - Journal of Biological …, 2005 - ASBMB
The c-Jun NH 2-terminal kinase (JNK) branch of the mitogen-activated protein kinase
signaling cascade has been implicated in the regulation of apoptosis in a variety of
mammalian cell types. In the heart, disagreement persists concerning the role that JNKs may
play in regulating apoptosis, since both pro-and antiapoptotic regulatory functions have
been reported in cultured cardiomyocytes. Here we report the first analysis of cardiomyocyte
cell death due to JNK inhibition or activation in vivo using genetically modified mice. Three …
signaling cascade has been implicated in the regulation of apoptosis in a variety of
mammalian cell types. In the heart, disagreement persists concerning the role that JNKs may
play in regulating apoptosis, since both pro-and antiapoptotic regulatory functions have
been reported in cultured cardiomyocytes. Here we report the first analysis of cardiomyocyte
cell death due to JNK inhibition or activation in vivo using genetically modified mice. Three …