IL-10–treated dendritic cells decrease airway hyperresponsiveness and airway inflammation in mice
T Koya, H Matsuda, K Takeda, S Matsubara… - Journal of allergy and …, 2007 - Elsevier
BACKGROUND: IL-10 affects dendritic cell (DC) function, but the effects on airway
hyperresponsiveness (AHR) and inflammation are not defined. OBJECTIVE: We sought to
determine the importance of IL-10 in regulating DC function in allergen-induced AHR and
airway inflammation. METHODS: DCs were generated from bone marrow in the presence or
absence of IL-10. In vivo IL-10–treated DCs from IL-10+/+ and IL-10−/− donors pulsed with
ovalbumin (OVA) were transferred to naive or sensitized mice before challenge. In recipient …
hyperresponsiveness (AHR) and inflammation are not defined. OBJECTIVE: We sought to
determine the importance of IL-10 in regulating DC function in allergen-induced AHR and
airway inflammation. METHODS: DCs were generated from bone marrow in the presence or
absence of IL-10. In vivo IL-10–treated DCs from IL-10+/+ and IL-10−/− donors pulsed with
ovalbumin (OVA) were transferred to naive or sensitized mice before challenge. In recipient …