Local treatment with IL-12 is an effective inhibitor of airway hyperresponsiveness and lung eosinophilia after airway challenge in sensitized mice
J Schwarze, E Hamelmann, G Cieslewicz… - Journal of allergy and …, 1998 - Elsevier
Background: Systemic administration of IL-12 can prevent airway hyperresponsiveness
(AHR) in mice after sensitization and repeated allergen challenge. However, systemic IL-12
has been associated with severe adverse effects. Objective: We determined whether IL-12
administration to the airways in a dose sufficiently low so as not to result in systemic effects
can modify allergic inflammation and AHR after allergen challenge. Methods: Mice were
sensitized to ovalbumin by intraperitoneal injection and challenged with ovalbumin aerosol …
(AHR) in mice after sensitization and repeated allergen challenge. However, systemic IL-12
has been associated with severe adverse effects. Objective: We determined whether IL-12
administration to the airways in a dose sufficiently low so as not to result in systemic effects
can modify allergic inflammation and AHR after allergen challenge. Methods: Mice were
sensitized to ovalbumin by intraperitoneal injection and challenged with ovalbumin aerosol …