Inhalation of low-dose endotoxin favors local TH2 response and primes airway phagocytes in vivo
BACKGROUND: We previously reported that inhalation of 5 μg of endotoxin (30,000
endotoxin units [EU]) induced airway neutrophilia and decreased phagocytosis by airway
monocytes, macrophages, and neutrophils. Conversely, we recently reported that very low
doses of endotoxin, which are not associated with neutrophil influx, enhance response to
allergen in the nasal and bronchial airway. OBJECTIVE: We sought to determine whether
endotoxin (0-10,000 EU) at doses that do not induce airway neutrophilia prime airway …
endotoxin units [EU]) induced airway neutrophilia and decreased phagocytosis by airway
monocytes, macrophages, and neutrophils. Conversely, we recently reported that very low
doses of endotoxin, which are not associated with neutrophil influx, enhance response to
allergen in the nasal and bronchial airway. OBJECTIVE: We sought to determine whether
endotoxin (0-10,000 EU) at doses that do not induce airway neutrophilia prime airway …