[HTML][HTML] Human papilloma virus 16 E6 oncoprotein inhibits retinoic X receptor-mediated transactivation by targeting human ADA3 coactivator
The expression of human papillomavirus (HPV) E6 oncoprotein is causally linked to high-
risk HPV-associated human cancers. We have recently isolated hADA3, the human
homologue of yeast transcriptional co-activator yADA3, as a novel E6 target. Human ADA3
binds to the high-risk (cancer-associated) but not the low-risk HPV E6 proteins and to
immortalization-competent but not to immortalization-defective HPV16 E6 mutants,
suggesting a role for the perturbation of hADA3 function in E6-mediated oncogenesis. We …
risk HPV-associated human cancers. We have recently isolated hADA3, the human
homologue of yeast transcriptional co-activator yADA3, as a novel E6 target. Human ADA3
binds to the high-risk (cancer-associated) but not the low-risk HPV E6 proteins and to
immortalization-competent but not to immortalization-defective HPV16 E6 mutants,
suggesting a role for the perturbation of hADA3 function in E6-mediated oncogenesis. We …