[HTML][HTML] Modest PGC-1α overexpression in muscle in vivo is sufficient to increase insulin sensitivity and palmitate oxidation in subsarcolemmal, not intermyofibrillar …
CR Benton, JG Nickerson, J Lally, XX Han… - Journal of Biological …, 2008 - ASBMB
PGC-1α overexpression in skeletal muscle, in vivo, has yielded disappointing and
unexpected effects, including disrupted cellular integrity and insulin resistance. These
unanticipated results may stem from an excessive PGC-1α overexpression in transgenic
animals. Therefore, we examined the effects of a modest PGC-1α overexpression in a single
rat muscle, in vivo, on fuel-handling proteins and insulin sensitivity. We also examined
whether modest PGC-1α overexpression selectively targeted subsarcolemmal (SS) …
unexpected effects, including disrupted cellular integrity and insulin resistance. These
unanticipated results may stem from an excessive PGC-1α overexpression in transgenic
animals. Therefore, we examined the effects of a modest PGC-1α overexpression in a single
rat muscle, in vivo, on fuel-handling proteins and insulin sensitivity. We also examined
whether modest PGC-1α overexpression selectively targeted subsarcolemmal (SS) …