[HTML][HTML] Down-regulation of BRCA2 expression by collagen type I promotes prostate cancer cell proliferation
L Moro, AA Arbini, E Marra, M Greco - Journal of Biological Chemistry, 2005 - ASBMB
BRCA2 is a tumor suppressor gene that when mutated confers an increased susceptibility to
developing breast and prostate carcinoma. Besides its role in mediating DNA repair, new
evidence suggests that BRCA2 may also play a role in suppressing cancer cell growth.
Because altered interactions between neoplastic cells and the surrounding extracellular
matrix (ECM) play a pivotal role in unchecked cancer cell proliferation and metastatic
progression, we hypothesized that the ECM may have an effect in BRCA2 expression. By …
developing breast and prostate carcinoma. Besides its role in mediating DNA repair, new
evidence suggests that BRCA2 may also play a role in suppressing cancer cell growth.
Because altered interactions between neoplastic cells and the surrounding extracellular
matrix (ECM) play a pivotal role in unchecked cancer cell proliferation and metastatic
progression, we hypothesized that the ECM may have an effect in BRCA2 expression. By …