Emerging roles of proteases in tumour suppression
C López-Otín, LM Matrisian - Nature reviews cancer, 2007 - nature.com
C López-Otín, LM Matrisian
Nature reviews cancer, 2007•nature.comProteases have long been associated with cancer progression because of their ability to
degrade extracellular matrices, which facilitates invasion and metastasis. However, recent
studies have shown that these enzymes target a diversity of substrates and favour all steps
of tumour evolution. Unexpectedly, the post-trial studies have also revealed proteases with
tumour-suppressive effects. These effects are associated with more than 30 different
enzymes that belong to three distinct protease classes. What are the clinical implications of …
degrade extracellular matrices, which facilitates invasion and metastasis. However, recent
studies have shown that these enzymes target a diversity of substrates and favour all steps
of tumour evolution. Unexpectedly, the post-trial studies have also revealed proteases with
tumour-suppressive effects. These effects are associated with more than 30 different
enzymes that belong to three distinct protease classes. What are the clinical implications of …
Abstract
Proteases have long been associated with cancer progression because of their ability to degrade extracellular matrices, which facilitates invasion and metastasis. However, recent studies have shown that these enzymes target a diversity of substrates and favour all steps of tumour evolution. Unexpectedly, the post-trial studies have also revealed proteases with tumour-suppressive effects. These effects are associated with more than 30 different enzymes that belong to three distinct protease classes. What are the clinical implications of these findings?
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