[HTML][HTML] Estrogen receptor α regulates expression of the orphan receptor small heterodimer partner

KD Lai, DC Harnish, MJ Evans - Journal of Biological Chemistry, 2003 - ASBMB
Hormonal status can influence diverse metabolic pathways. Small heterodimer partner
(SHP) is an orphan nuclear receptor that can modulate the activity of several transcription
factors. Estrogens are here shown to directly induce expression of the SHP in the mouse
and rat liver and in human HepG2 cells. SHP is rapidly induced within 2 h following
treatment of mice with ethynylestradiol (EE) or the estrogen receptor α (ERα)-selective
compound propyl pyrazole triol (PPT). SHP induction by these estrogens is completely …