Angiotensin II infusion induces site-specific intra-laminar hemorrhage in macrophage colony-stimulating factor-deficient mice
F Babamusta, DL Rateri, JJ Moorleghen, DA Howatt… - Atherosclerosis, 2006 - Elsevier
Angiotensin II (AngII) infusion promotes macrophage infiltration into the aortic wall resulting
in several forms of vascular pathology. To determine the causal role of macrophages in
these vascular diseases, we used osteopetrotic (op) male mice in which a natural mutation
ablates production of M-CSF and results in severe depletion of monocytes. AngII infusion
into apoE−/− mice resulted in increased atherosclerosis that was attenuated in op mice.
AngII infusion in op mice unexpectedly produced grossly discernable thickening of the …
in several forms of vascular pathology. To determine the causal role of macrophages in
these vascular diseases, we used osteopetrotic (op) male mice in which a natural mutation
ablates production of M-CSF and results in severe depletion of monocytes. AngII infusion
into apoE−/− mice resulted in increased atherosclerosis that was attenuated in op mice.
AngII infusion in op mice unexpectedly produced grossly discernable thickening of the …