Insulin is important for maintaining the responsiveness of the liver to growth hormone (GH).
Insulin deficiency results in a decrease in liver GH receptor (GHR) expression, which can be
reversed by insulin administration. In osteoblasts, continuous insulin treatment decreases
the fraction of cellular GHR localized to the plasma membrane. Thus, it is not clear whether
hyperinsulinemia results in an enhancement or inhibition of GH action. We asked whether
continuous insulin stimulation, similar to what occurs in hyperinsulinemic states, results in …