[HTML][HTML] The signal transduction of the growth hormone receptor is regulated by the ubiquitin/proteasome system and continues after endocytosis
CMA dos Santos, P van Kerkhof, GJ Strous - Journal of Biological …, 2001 - ASBMB
The growth hormone receptor (GHR) intracellular domain contains all of the information
required for signal transduction as well as for endocytosis. Previously, we showed that the
proteasome mediates the clathrin-mediated endocytosis of the GHR. Here, we present
evidence that the proteasomal inhibitor MG132 prolongs the GH-induced activity of both
GHR and JAK2, presumably through stabilization of GHR and JAK2 tyrosine
phosphorylation. If proteasomal inhibitor was combined with ligand in an endocytosis …
required for signal transduction as well as for endocytosis. Previously, we showed that the
proteasome mediates the clathrin-mediated endocytosis of the GHR. Here, we present
evidence that the proteasomal inhibitor MG132 prolongs the GH-induced activity of both
GHR and JAK2, presumably through stabilization of GHR and JAK2 tyrosine
phosphorylation. If proteasomal inhibitor was combined with ligand in an endocytosis …