Stimulation of lipolysis but not of leptin release by growth hormone is abolished in adipose tissue from Stat5a and b knockout mice
JN Fain, JH Ihle, SW Bahouth - Biochemical and biophysical research …, 1999 - Elsevier
JN Fain, JH Ihle, SW Bahouth
Biochemical and biophysical research communications, 1999•ElsevierThe present studies examined the effects of growth hormone (GH) on lipolysis and leptin
release by adipose tissue from mice incubated for 24 h in primary culture. In adipose tissue
from control mice GH enhanced lipolysis without affecting leptin release. The lipolytic action
of GH was unaffected in adipose tissue from Stat5b−/− male mice but leptin release was
enhanced by GH in fat from Stat5b−/− mice. In adipose tissue from Stat5ab−/− female mice
no significant lipolytic action of GH was seen but leptin release was enhanced by GH. An …
release by adipose tissue from mice incubated for 24 h in primary culture. In adipose tissue
from control mice GH enhanced lipolysis without affecting leptin release. The lipolytic action
of GH was unaffected in adipose tissue from Stat5b−/− male mice but leptin release was
enhanced by GH in fat from Stat5b−/− mice. In adipose tissue from Stat5ab−/− female mice
no significant lipolytic action of GH was seen but leptin release was enhanced by GH. An …
The present studies examined the effects of growth hormone (GH) on lipolysis and leptin release by adipose tissue from mice incubated for 24 h in primary culture. In adipose tissue from control mice GH enhanced lipolysis without affecting leptin release. The lipolytic action of GH was unaffected in adipose tissue from Stat5b−/− male mice but leptin release was enhanced by GH in fat from Stat5b−/− mice. In adipose tissue from Stat5ab−/− female mice no significant lipolytic action of GH was seen but leptin release was enhanced by GH. An insulin-like effect of GH on glucose conversion to lactate was also seen in mice deficient in Stat5ab−/−. These results suggest that the lipolytic action of GH involves the Stat5 proteins while the insulin-like effects of GH on glucose metabolism and leptin release involve different mechanisms.
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